货号	规格	价格	上海	北京	珠海	重庆	武汉
V47737-1mg	≥98%	￥1340.00 V47737-1mg ￥1340.00 3-5天	0 货期：3-5天	-	-	-	-
V47737-5mg	≥98%	￥2980.00 V47737-5mg ￥2980.00 3-5天	0 货期：3-5天	-	-	-	-
V47737-10mg	≥98%	￥4780.00 V47737-10mg ￥4780.00 3-5天	0 货期：3-5天	-	-	-	-
V47737-25mg	≥98%	￥8630.00 V47737-25mg ￥8630.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis.

靶点：

IC50: 39 nM (trypsin), 950 nM (plasmin) and 1.9 μM (thrombin)

体外研究：

Patamostat (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].
Patamostat (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis[1].
Patamostat (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats[2].

体内研究：

Patamostat (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner.
Patamostat (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis.
Patamostat (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats.

参考文献：

1. K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93.
2. T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9.

保存条件：

2-8°C, 避光, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.424 ml	12.122 ml	24.245 ml
5 mM	0.485 ml	2.424 ml	4.849 ml
10 mM	0.242 ml	1.212 ml	2.424 ml
50 mM	0.048 ml	0.242 ml	0.485 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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