货号	规格	价格	上海	北京	珠海	重庆	武汉
V47775-5mg	≥98%	￥940.00 V47775-5mg ￥940.00 3-5天	0 货期：3-5天	-	-	-	-
V47775-10mg	≥98%	￥1480.00 V47775-10mg ￥1480.00 3-5天	0 货期：3-5天	-	-	-	-
V47775-25mg	≥98%	￥2790.00 V47775-25mg ￥2790.00 3-5天	0 货期：3-5天	-	-	-	-
V47775-50mg	≥98%	￥4500.00 V47775-50mg ￥4500.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Safusidenib (AB-291; DS-1001) is an orally bioavailable, selective mutant IDH1 inhibitor. Safusidenib strongly inhibits mutant IDH1 but not wild-type IDH1. Safusidenib impairs tumor activity in chondrosarcoma. Safusidenib exhibits activity against IDH1R132H, and IDH1R132C with IC50s of 15, and 130 nM in assays without any preincubation, respectively.

体外研究：

Safusidenib (DS-1001b) impairs the proliferation of IDH1-mutated chondrosarcoma cell lines and decreases 2-HG levels.
Safusidenib impairs the proliferation of IDH1 mutant chondrosarcoma cell lines in a dose-dependent manner, whereas Safusidenib has little effect on the proliferation of the IDH wild-type cell lines OUMS27 and NDCS-1; GI50 values for JJ012, L835, OUMS27, and NDCS-1 cells are 81?nM (day 14), 77?nM (6 weeks), >10?μM (day 10), and >10?μM (day 10), respectively.
Safusidenib (1, and 10?μM; for 6 weeks) markedly upregulates SOX9, a key regulator of chondrocyte differentiation, at the protein level.
Safusidenib (1 μM) significantly upregulates CDKN1C at the protein level.
Safusidenib (DS-1001b) exhibits activity against IDH1 or IDH2 enzymes with IC50s of 8.4, 11, and 180 nM for IDH1R132H, IDH1R132C, and IDH1WT in assays conducted with a 2-hour preincubation step.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.866 ml	9.332 ml	18.664 ml
5 mM	0.373 ml	1.866 ml	3.733 ml
10 mM	0.187 ml	0.933 ml	1.866 ml
50 mM	0.037 ml	0.187 ml	0.373 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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