货号	规格	价格	上海	北京	珠海	重庆	武汉
V47792-1mg	≥98%	￥2170.00 V47792-1mg ￥2170.00 3-5天	0 货期：3-5天	-	-	-	-
V47792-5mg	≥98%	￥4790.00 V47792-5mg ￥4790.00 3-5天	0 货期：3-5天	-	-	-	-
V47792-10mg	≥98%	￥7670.00 V47792-10mg ￥7670.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC50 value of 112 nM. IDO2-IN-1 can be used for inflammatory autoimmunity research.

靶点：

IDO1:411 nM (IC50); IDO2:112 (IC50)

体外研究：

The Adjuvant arthritis (AA) model and Collagen-induced arthritis (CIA) model have similar pathogenesis and pathological characteristics to human rheumatoid arthritis (RA).

IDO2-IN-1 (compound 22) (100 mg/kg; p.o.; once dose) exhibits excellent anti-inflammatory activity, higher than naproxen, a prescription drug reducing pain, swelling, and joint stiffness from arthritis[1].

IDO2-IN-1 (25, 50, 100 mg/kg; i.p.; once daily, for 19 d) exhibits excellent inhibitory effect on mice paw swelling, shows efficacy in a collagen-induced arthritis model in mice[1].

IDO2-IN-1 (30, 60, 120 mg/kg; i.p.; once daily, for 15 d) inhibits joint inflammation and displays potential effect in autoimmune arthritis improvement[1].

Pharmacokinetic Profile in Rat[1]

体内研究：

IDO2-IN-1 (compound 22) shows stronger inhibition on IDO2 (IC50 =112 nM) over IDO1 (IC50 =411 nM).
IDO2-IN-1 inhibits hIDO1 expression (EC50=633 nM) in HeLa cell-based IDO1/kynurenine assay, co-incubated with hIFN-γ (100 ng/mL final concentration), which is used for producing N-formylkynurenine.

保存条件：

2-8°C, 避光, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.847 ml	9.236 ml	18.472 ml
5 mM	0.369 ml	1.847 ml	3.694 ml
10 mM	0.185 ml	0.924 ml	1.847 ml
50 mM	0.037 ml	0.185 ml	0.369 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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