货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V47823-1mg	≥98%	￥800.00 V47823-1mg ￥800.00 3-5天	0 货期：3-5天	-	-	-	-
V47823-5mg	≥98%	￥2800.00 V47823-5mg ￥2800.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Ethylmalonic acid-d5 is the deuterium labeled Ethylmalonic acid . Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation.

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

参考文献：

1. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
2. Cecatto C, et al. Ethylmalonic acid induces permeability transition in isolated brain mitochondria. Neurotox Res. 2014 Aug;26(2):168-78.
3. Leipnitz G, et al. Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro. Neurochem Res. 2003 May;28(5):771-7.
4. Schuck PF, et al. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochem Res. 2010 Feb;35(2):298-305.
5. Schuck PF, et al. Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration. PLoS One. 2015 May 26;10(5):e0126606.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	7.291 ml	36.456 ml	72.913 ml
5 mM	1.458 ml	7.291 ml	14.583 ml
10 mM	0.729 ml	3.646 ml	7.291 ml
50 mM	0.146 ml	0.729 ml	1.458 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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