| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V47904-1mg |
≥98% | ￥1030.00 |
货期：3-5天 | - | - | - | - |
|
V47904-5mg |
≥98% | ￥2590.00 |
货期：3-5天 | - | - | - | - |
|
V47904-10mg |
≥98% | ￥4190.00 |
货期：3-5天 | - | - | - | - |
|
V47904-25mg |
≥98% | ￥7530.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors. | ||||||||||||||||||||
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| 靶点： | EZH2 | ||||||||||||||||||||
| 体内研究： | Knockdown EZH2 in A549 cells results in the decrease of cell sensitivity to DM-01 at 50 and 100 μM concentrations. DM-01 also shows comparable inhibitory activity for K562 cells with an IC50 value of 58.706 μΜ. DM-01 (5 and 10 μM; 24 hours) strongly inhibits the activity of EZH2 and results in abolished H3K27me expression in K562 cells. DM-01 (5 and 10 μM) also increases the transcription expression of DIRAS3 in a dose dependent manner, a tumor suppressor in downstream of EZH2. |
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| 保存条件： | 2-8°C, 氮气保存 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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