| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V47930-5mg |
≥98% | ￥690.00 |
货期：3-5天 | - | - | - | - |
|
V47930-10mg |
≥98% | ￥1070.00 |
货期：3-5天 | - | - | - | - |
|
V47930-25mg |
≥98% | ￥2150.00 |
货期：3-5天 | - | - | - | - |
|
V47930-50mg |
≥98% | ￥3440.00 |
货期：3-5天 | - | - | - | - |
|
V47930-100mg |
≥98% | ￥5490.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model. | ||||||||||||||||||||
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| 体外研究： | Mps1-IN-3 hydrochloride (0.3-10 μM) inhibits the marker of mitotic cells cyclin B in a dose-dependent manner. Mps1-IN-3 hydrochloride (2 μM) causes a dose-dependent escape from a checkpoint-mediated mitotic arrest. Mps1-IN-3 hydrochloride (1-15 μM) inhibits the proliferation of U251 glioblastoma cells with an IC50 value of ~5 µM. |
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| 体内研究： | Mps1-IN-3 hydrochloride (2 mg/kg; IV, twice a week, for 3 weeks) effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft models. | ||||||||||||||||||||
| 参考文献： | 1. Tannous BA, et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31. |
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| 保存条件： | -20°C, 干燥 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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