货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V47939-1mg	≥98%	￥2720.00 V47939-1mg ￥2720.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V47939-1mg

≥98%

￥2720.00

货期：3-5天

产品描述：

M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity.

靶点：

A2AR,A2BR

体外研究：

Metabolically stressful conditions, including inflammation and cancer, induces extracellular concentrations of adenosine increase.

M1069 dose-dependently suppresses 5’-N-ethylcarboxamide adenosine (stable analog of adenosine)-stimulated cyclic adenosine monophosphate (cAMP) and phosphorylated cAMP- response element binding protein (pCREB) induction, inhibits interleukin (IL)-2 production.

M1069 suppresses vascular endothelial growth factor (VEGF) production from human macrophages in adenosine-rich settings.

M1069 inhibits protumorigenic cytokine secretion, such as CXCL1, CXCL5 and granulocyte-colony stimulating factor, and reduces IL-12 secretion from adenosine-differentiated dendritic cells.

M1069 enhances T-cells activation in adenosine-differentiated dendritic cells.

体内研究：

M1069 inhibits breast tumor (CD73hi/adenosine-rich 4T1 syngeneic) growth in vivo in mice and enhances chemotherapeutic agents efficacy.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.83 ml	9.148 ml	18.295 ml
5 mM	0.366 ml	1.83 ml	3.659 ml
10 mM	0.183 ml	0.915 ml	1.83 ml
50 mM	0.037 ml	0.183 ml	0.366 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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