货号	规格	价格	上海	北京	珠海	重庆	武汉
V47989-5mg	≥98%	￥2190.00 V47989-5mg ￥2190.00 3-5天	0 货期：3-5天	-	-	-	-
V47989-10mg	≥98%	￥3590.00 V47989-10mg ￥3590.00 3-5天	0 货期：3-5天	-	-	-	-
V47989-25mg	≥98%	￥6470.00 V47989-25mg ￥6470.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Autophagy inducer 3 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins.

体外研究：

Autophagy inducer 3 (compound 26b) (10 μM; 48 hours) effectively inhibits cell growth in diverse breast, lung and colon cancer cell lines.
Autophagy inducer 3 (0-10 μM; 48 hours) exhibits potent antiproliferative activity in COLO-205, LOVO, HT-29, DLD-1, SW48 and SW-620 with IC50s of 2.03 μM, 3.33 μM, 4.15 μM, 4.46 μM, 3.14 μM, 1.86 μM, respectively; and shows low cytotoxicity in normal human colon fibroblast CCD-18Co with IC50 over 10 μM.
Autophagy inducer 3 (7.5 μM; 18 hours) promotes non apoptotic cell death in DLD-1 cells by cellular granularity through vacuole formation and increase Annexin-V positive cells as well as PARP cleavage; and robustly induces the expression of classical autophagy markers like Beclin-1, Atg3, Atg5 and Atg7.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.648 ml	13.242 ml	26.483 ml
5 mM	0.53 ml	2.648 ml	5.297 ml
10 mM	0.265 ml	1.324 ml	2.648 ml
50 mM	0.053 ml	0.265 ml	0.53 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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