货号	规格	价格	上海	北京	珠海	重庆	武汉
V48008-5mg	≥98%	￥910.00 V48008-5mg ￥910.00 3-5天	0 货期：3-5天	-	-	-	-
V48008-10mg	≥98%	￥1480.00 V48008-10mg ￥1480.00 3-5天	0 货期：3-5天	-	-	-	-
V48008-50mg	≥98%	￥4010.00 V48008-50mg ￥4010.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with Kis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors.

靶点：

cIAP1:1.9 nM (Ki); cIAP2:5.1 nM (Ki); XIAP:66.4 nM (Ki)

体外研究：

Xevinapant (AT-406) hydrochloride is very effective in inhibition of tumor growth in the MDA-MB-231 xenograft model, and has minimal toxicity to animals[1]. Xevinapant hydrochloride evaluated for its pharmacokinetic (PK) properties in mice, rats, non-human primates and dogs[1].

体内研究：

Xevinapant (AT-406) hydrochloride potently inhibits cell growth in the MDA-MB-231 breast and SK-OV-3 ovarian cancer cell lines with IC50=144 nM and 142 nM, respectively. Xevinapant (0-3 μM; 0-48 horus) hydrochloride effectively induces cell death in a time- and dose-dependent manner.

参考文献：

1. Cai Q, Sun H, Peng Y, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011;54(8):2714-2726.
2. Brunckhorst MK, et al. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer Biol Ther. 2012;13(9):804-811.

保存条件：

-20°C, 避光,干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.672 ml	8.359 ml	16.717 ml
5 mM	0.334 ml	1.672 ml	3.343 ml
10 mM	0.167 ml	0.836 ml	1.672 ml
50 mM	0.033 ml	0.167 ml	0.334 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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