货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V48061-1mg	≥98%	￥2990.00 V48061-1mg ￥2990.00 3-5天	0 货期：3-5天	-	-	-	-
V48061-5mg	≥98%	￥6630.00 V48061-5mg ￥6630.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

GNE-274 is a structural analog of the ER degrader GDC-0927 and is a non-degrader. GNE-274 does not induce conversion of ER in breast cancer cell lines and functions as a partial ER agonist (partial ER agonist). GNE-274 increases the chromatin accessibility of ER-DNA binding sites, whereas GDC-0927 does not. GNE-274 is an effective ER ligand binding domain (LBD) inhibitor. GNE-274 can be used in cancer research.

体外研究：

GNE-274 (0.1 nM-1000 nM; 4 hours) fails to trigger increased ER turnover in MCF7, MD-134, HCC1500 and CAMA cells.
GNE-274 (1-1000 nM; 7-10 days) potently inhibits cellular proliferation, exhibiting greater potency than fulvestrant, 4-OHT, AZD9496, and GDC-0810 in E2-stimulated ER+ breast cancer cell lines.
In transposaseaccessible chromatin sequencing (ATAC-seq) assay, GNE-274 increase chromatin accessibility at ER-DNA binding sites, it significantly alters chromatin accessibility at 594 sites. But GDC-0927 has considerably less impact on chromatin accessibility.

保存条件：

2-8°C, 避光, 氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.185 ml	10.927 ml	21.855 ml
5 mM	0.437 ml	2.185 ml	4.371 ml
10 mM	0.219 ml	1.093 ml	2.185 ml
50 mM	0.044 ml	0.219 ml	0.437 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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