货号	规格	价格	上海	北京	珠海	重庆	武汉
V48097-1mg	≥98%	￥1670.00 V48097-1mg ￥1670.00 3-5天	0 货期：3-5天	-	-	-	-
V48097-5mg	≥98%	￥3690.00 V48097-5mg ￥3690.00 3-5天	0 货期：3-5天	-	-	-	-
V48097-10mg	≥98%	￥5910.00 V48097-10mg ￥5910.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents. Antimalarial activity.

体外研究：

HLI373 (3-15 μM; 15 hours) selectively kills tumor cells harboring wild type p53.
HLI373 (10-50 μM) stabilizes cellular Hdm2 in a dose-dependent manner.
HLI373 (3 μM) activates p53 transcription.
HLI373 selectively inhibits auto-ubiquitylation of Hdm2.
Co-transfection with plasmids encoding p53 and Hdm2 results in degradation of p53. Incubation with HLI373 (5-10 μM; 8 hours) blocks p53 degradation. HLI373 increases p53 and Hdm2 protein levels in cells.
HLI 373 also shows lower IC50 values (below 6 μM) against both chloroquine-sensitive P. falciparum D6 strain (PfD6) and chloroquine-resistant P. falciparum W2 strain (PfW2) and exhibits early growth inhibition.
HLI-373 is a MDM2 inhibitor interrupting its ubiquitin E3 ligase activity, could abolish the ubiquitylation of its substrate protein p53. HLI-373 targets the C-terminus functioning as an E3 ubiquitin ligase.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.414 ml	12.068 ml	24.135 ml
5 mM	0.483 ml	2.414 ml	4.827 ml
10 mM	0.241 ml	1.207 ml	2.414 ml
50 mM	0.048 ml	0.241 ml	0.483 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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