| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V48181-1mg |
≥98% | ￥740.00 |
货期：3-5天 | - | - | - | - |
|
V48181-5mg |
≥98% | ￥1640.00 |
货期：3-5天 | - | - | - | - |
|
V48181-10mg |
≥98% | ￥2650.00 |
货期：3-5天 | - | - | - | - |
|
V48181-25mg |
≥98% | ￥4930.00 |
货期：3-5天 | - | - | - | - |
|
V48181-50mg |
≥98% | ￥7890.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. | ||||||||||||||||||||
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| 靶点： | sPLA2:9 nM (IC50) | ||||||||||||||||||||
| 体外研究： | Varespladib sodium treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib sodium is 16.1 mg/kg[1]. | ||||||||||||||||||||
| 体内研究： | Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment results in complete inhibition of the RA-induced increase in MUC16 protein detected in cell lysates at both time points. Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment significantly inhibits RA-induced MUC16 expression by 100% at 24 hours and 99% at 48 hours. |
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| 保存条件： | 2-8°C, 干燥 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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