货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V48298-1mg	≥98%	￥2590.00 V48298-1mg ￥2590.00 3-5天	0 货期：3-5天	-	-	-	-
V48298-5mg	≥98%	￥6960.00 V48298-5mg ￥6960.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Metaxalone-d3 is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia.

靶点：

PPARγ and MAO-A[4]

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.459 ml	22.295 ml	44.589 ml
5 mM	0.892 ml	4.459 ml	8.918 ml
10 mM	0.446 ml	2.229 ml	4.459 ml
50 mM	0.089 ml	0.446 ml	0.892 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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