货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V48438-1mg	≥90%	￥8590.00 V48438-1mg ￥8590.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V48438-1mg

≥90%

￥8590.00

货期：3-5天

产品描述：

PROTAC EGFR degrader 3 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 3 shows excellent cellular activity against the H1975 and HCC827 cells with high selectively. PROTAC EGFR degrader 3 shows that the lysosome is involved in the degradation process of EGFR mutant degradation.

体外研究：

PROTAC EGFR degrader 3 (compound CP17) shows anti-proliferative activity of PROTACs with IC50s of 32 nM, 1.60 nM, >10000nM for H1975 (EGFRL858/T790M), HCC827 (EGFRdel19), A431 (EGFRWT) cells, respectively.
PROTAC EGFR degrader 3 (0, 10, 100, 1000, 10000 nM) exhibits poor cellular activity with IC50 of 481 nM, 669 nM for Ba/F3 (EGFRdel19/T790M/C797S) and Ba/F3 (EGFRL858/T790M/C797S) cells, respectively.
PROTAC EGFR degrader 3 (0-10000 nM) suppresses the proliferation of the PC9 (EGFRdel19/T790M/C797S) and H1975 (EGFRL858/T790M/C797S) cells, respectively.
PROTAC EGFR degrader 3 (30 nM; 0-72 h) decreases the expression level of EGFRL858/T790M after 8h, and degradation rate maximizes after 48 h.
PROTAC EGFR degrader 3 (0.3, 1, 3, 10, 100, 300 nM; 24, 48 h) induces the degradation of EGFRL858/T790M and EGFRdel19 with DC50s of 1.56 nM and 0.49 nM, respectively.
PROTAC EGFR degrader 3 (100, 1000 nM; 24 h) shows selective against mutant EGFR in the H1975 and HCC827 cells.
PROTAC EGFR degrader 3 (0.3, 1, 3, 10, 100, 300 nM; 24 h) effectively blocks EGFR singnal transduction, leading to cell proliferation inhibition.
PROTAC EGFR degrader 3 (30 nM) induces EGFR mutant degradation, and the lysosome is involved in the degradation process.

保存条件：

2-8°C, 避光, 氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.915 ml	4.577 ml	9.154 ml
5 mM	0.183 ml	0.915 ml	1.831 ml
10 mM	0.092 ml	0.458 ml	0.915 ml
50 mM	0.018 ml	0.092 ml	0.183 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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