| 产品描述: | [Glu1]-Fibrinopeptide B 衍生自纤维蛋白肽B氨基酸残基1-14。人纤维蛋白肽B(hFpB)是来自纤维蛋白原B β链的凝血酶衍生的蛋白水解裂解产物,可用于刺激中性粒细胞 (PMN),单核细胞和成纤维细胞。 |
| 体外研究: |
hFpB causes directed cell migration of PMN and fibroblasts that is optimal at approximately 10 nM. hFpB causes a rapid, dose-dependent increase in PMN cytoskeletal associated actin, but unlike fMLP, hFpB does not cause PMN aggregation, release of lysosomal enzymes (lysozyme and beta-glucuronidase), or the production of superoxide anion. These results suggest that hFpB may have a role in recruiting PMN and fibroblasts at sites of fibrin deposition and turnover. The capacity of hFpB to cause PMN chemotaxis without causing concurrent release of lysosomal enzymes or the production of superoxide anion is further evidence for the complexity of PMN responses to chemotactic agents. |
| 参考文献: |
1. Senior RM, et al. Effects of fibrinogen derivatives upon the inflammatory response. Studies with human fibrinopeptide B. J Clin Invest. 1986 Mar;77(3):1014-9.
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| 保存条件: |
-20°C, 干燥, 避光, 氮气保存 |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
0.637 ml |
3.184 ml |
6.367 ml |
| 5 mM |
0.127 ml |
0.637 ml |
1.273 ml |
| 10 mM |
0.064 ml |
0.318 ml |
0.637 ml |
| 50 mM |
0.013 ml |
0.064 ml |
0.127 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |