货号	规格	价格	上海	北京	珠海	重庆	武汉
V48546-1mg	≥90%	￥1220.00 V48546-1mg ￥1220.00 现货	4 4	-	-	-	-
V48546-5mg	≥90%	￥2690.00 V48546-5mg ￥2690.00 现货	3 3	-	-	-	-
V48546-10mg	≥90%	￥4300.00 V48546-10mg ￥4300.00 现货	3 3	-	-	-	-
V48546-25mg促销	≥90%	￥9160.00 ￥8240.00 V48546-25mg ￥8240.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection.

Fructosyl-lysine (Fructoselysine) 是葡萄糖与赖氨酸通过美拉德反应生成的一种氨基糖基化产物 (amadori glycation)。Fructosyl-lysine 是葡萄糖烷的前体，葡萄糖烷是一种赖氨酸-精氨酸蛋白交联物，可作为糖尿病中检测的指标。

靶点：

IC50: precursor to glucosepane

体外研究：

Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts.
Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts.
Fructosyl-lysine (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose.

体内研究：

Fructosyl-lysine and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats.

参考文献：

1. Rabbani N, et al. Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes. Diabetes. 2015 Jan;64(1):9-11.
2. Karachalias N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.243 ml	16.216 ml	32.433 ml
5 mM	0.649 ml	3.243 ml	6.487 ml
10 mM	0.324 ml	1.622 ml	3.243 ml
50 mM	0.065 ml	0.324 ml	0.649 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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