| 产品描述： | PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM. |
| 靶点： |
IC50: 5.6 μM (Interaction between PTK7 and β-catenin); 157.1 μM (Interaction between p53 and MDM2) |
| 参考文献： |
1. Ganier L, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer[J]. ACS Chemical Biology, 2022, 17(5): 1061-1072. |
| 保存条件： |
2-8°C, 避光 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.768 ml |
8.841 ml |
17.682 ml |
| 5 mM |
0.354 ml |
1.768 ml |
3.536 ml |
| 10 mM |
0.177 ml |
0.884 ml |
1.768 ml |
| 50 mM |
0.035 ml |
0.177 ml |
0.354 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
