货号	规格	价格	上海	北京	珠海	重庆	武汉
V48581-1mg	≥90%	￥2200.00 V48581-1mg ￥2200.00 3-5天	0 货期：3-5天	-	-	-	-
V48581-5mg	≥90%	￥5500.00 V48581-5mg ￥5500.00 3-5天	0 货期：3-5天	-	-	-	-
V48581-10mg	≥90%	￥8770.00 V48581-10mg ￥8770.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Tat-NR2BAA is the control peptide of Tat-NR2B9c , inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95.

体外研究：

Tat-NR2BAA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue.
Tat-NR2Baa (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell. But Tat-NR2Baa has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c .
Tat-NR2Baa (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.404 ml	2.02 ml	4.041 ml
5 mM	0.081 ml	0.404 ml	0.808 ml
10 mM	0.04 ml	0.202 ml	0.404 ml
50 mM	0.008 ml	0.04 ml	0.081 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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