货号	规格	价格	上海	北京	珠海	重庆	武汉
V48602-1mg	≥90%	￥870.00 V48602-1mg ￥870.00 3-5天	0 货期：3-5天	-	-	-	-
V48602-5mg	≥90%	￥2190.00 V48602-5mg ￥2190.00 3-5天	0 货期：3-5天	-	-	-	-
V48602-10mg	≥90%	￥3510.00 V48602-10mg ￥3510.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.

靶点：

KRAS-SOS1,KRas G12C:140 nM (EC50); KRas G12D:109 nM (EC50); KRas G12V:154 nM (EC50); KRas G12S:155 nM (EC50); KRas Q61H:175 nM (EC50)

体外研究：

SAH-SOS1A TFA (0.625-40 μM; 24 hours) dose-responsively impairs the viability of cancer cells bearing G12D, G12C, G12V, G12S, G13D, and Q61H mutations with IC50 values in the 5- to 15-μM range. Cancer cells expressing wild-type KRAS, such as HeLa and Colo320-HSR cells, are similarly affected.
SAH-SOS1A TFA (5-40 μM; 4 hours) dose-responsively inhibits MEK1/2, ERK1/2, and AKT phosphorylation.

体内研究：

SAH-SOS1A (0.2 μL of 10 mM solution; injection; 48 hours; abdomens of D. melanogaster Ras85DV12/ActinGS) treatment notably decreases the phosphorylation state of ERK1/2.

保存条件：

-80°C, 干燥, 避光, 氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.434 ml	2.172 ml	4.345 ml
5 mM	0.087 ml	0.434 ml	0.869 ml
10 mM	0.043 ml	0.217 ml	0.434 ml
50 mM	0.009 ml	0.043 ml	0.087 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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