货号	规格	价格	上海	北京	珠海	重庆	武汉
V48638-1mg	≥90%	￥1290.00 V48638-1mg ￥1290.00 3-5天	0 货期：3-5天	-	-	-	-
V48638-5mg	≥90%	￥3440.00 V48638-5mg ￥3440.00 3-5天	0 货期：3-5天	-	-	-	-
V48638-10mg	≥90%	￥5510.00 V48638-10mg ￥5510.00 3-5天	0 货期：3-5天	-	-	-	-
V48638-25mg	≥90%	￥9920.00 V48638-25mg ￥9920.00 3-5天	0 货期：3-5天	-	-	-	-
V48638-50mg	≥90%	￥15800.00 V48638-50mg ￥15800.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

FXR agonist 3 is an anti-NASH agent, acting by activating FXR. FXR agonist 3 inhibits COL1A1, TGF-β1, α-SMA and TIMP1 expression with anti-fibrogenic activity. FXR agonist 3 significantly reduces liver steatosis and inflammation, improves liver fibrosis level.

体外研究：

FXR agonist 3 (compound 3a) (200 mg/kg; p.o.; daily for 4 weeks) significantly attenuates the degree of liver fibrosis in choline-deficient, l-amino acid-defined, high-fat diet (CDAHFD)-induced NASH mice model[1].
FXR agonist 3 (200 mg/kg; p.o.; daily for 4 weeks) also exerts liver-protective and anti-fibrosis activities in bile duct ligation (BDL)-induced fibrosis rat model[1].

体内研究：

FXR agonist 3 (compound 3a) (5 μM; 24 h) shows anti-fibrogenic activity, decreases multiple fibrogenic biomarkers level in LX-2 cells in a dose-dependent manner.
FXR agonist 3 shows cytotoxic concentration against LX2 cells with an CC50 value of 70.36 μM.

Metabolic stability of FXR agonist 3 in human, rat and mouse liver microsomes

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.914 ml	9.571 ml	19.141 ml
5 mM	0.383 ml	1.914 ml	3.828 ml
10 mM	0.191 ml	0.957 ml	1.914 ml
50 mM	0.038 ml	0.191 ml	0.383 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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