货号	规格	价格	上海	北京	珠海	重庆	武汉
V48725-1mg	≥90%	￥1240.00 V48725-1mg ￥1240.00 3-5天	0 货期：3-5天	-	-	-	-
V48725-5mg	≥90%	￥3490.00 V48725-5mg ￥3490.00 3-5天	0 货期：3-5天	-	-	-	-
V48725-10mg	≥90%	￥5590.00 V48725-10mg ￥5590.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.

体外研究：

2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria.
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates.
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport.
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.675 ml	18.376 ml	36.751 ml
5 mM	0.735 ml	3.675 ml	7.35 ml
10 mM	0.368 ml	1.838 ml	3.675 ml
50 mM	0.074 ml	0.368 ml	0.735 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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