货号	规格	价格	上海	北京	珠海	重庆	武汉
V48942-5mg	≥90%	￥2940.00 V48942-5mg ￥2940.00 3-5天	0 货期：3-5天	-	-	-	-
V48942-10mg	≥90%	￥4790.00 V48942-10mg ￥4790.00 3-5天	0 货期：3-5天	-	-	-	-
V48942-25mg	≥90%	￥8900.00 V48942-25mg ￥8900.00 3-5天	0 货期：3-5天	-	-	-	-
V48942-50mg	≥90%	￥11700.00 V48942-50mg ￥11700.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC50 values in the micro-molar range in human tumor cells and induces apoptosis.

体外研究：

The efficacy of ADPM01 is completely ablated at a 1% oxygen level in Hela and MRC5 cell lines. ADPM06 displays only a partial reduction in light-induced activity in hypoxic as compared to normoxic conditions.
ADPM06-PDT induces ER stress and unfolded protein response.
ADPM06-PDT induces apoptosis and involves caspase enzymatic activity.
Following ADPM06-PDT, a rapid processing of XBP1 mRNA occurs resulting in the removal of an intron from the mRNA in a spliceosome-independent manner, a post-transcriptional modification catalyzed by the action of activated inositol-requiring protein 1 (IRE1).
ADPM06-PDT-induced apoptosis involves the generation of ROS.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.398 ml	6.991 ml	13.982 ml
5 mM	0.28 ml	1.398 ml	2.796 ml
10 mM	0.14 ml	0.699 ml	1.398 ml
50 mM	0.028 ml	0.14 ml	0.28 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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