Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke.
体内研究:
Tenecteplase (0.25-2.5 mg/kg, iv, single dose) 在最初 30 分钟内给药可减少梗死体积,改善小鼠模型中凝血酶 (thrombin) 诱发的缺血性血栓栓塞。