货号	价格	上海	北京	珠海	重庆	武汉
V49274-5mg	￥660.00 V49274-5mg ￥660.00 3-5天	0 货期：3-5天	-	-	-	-
V49274-10mg	￥880.00 V49274-10mg ￥880.00 3-5天	0 货期：3-5天	-	-	-	-
V49274-25mg	￥1440.00 V49274-25mg ￥1440.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Fadrozole hydrochloride hemihydrate is an orally active, potent, selective and nonsteroidal aromatase inhibitor, with an IC50 of 6.4 nM. Fadrozole hydrochloride hemihydrate inhibits the production of estrogen and progesterone, with IC50 values of 0.03 and 120 μM. Fadrozole hydrochloride hemihydrate shows prevention of spontaneous tumours. Fadrozole hydrochloride hemihydrate can be used for the research of estrogen-dependent disease and cancer.

体外研究：

Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride hemihydrate.

体内研究：

Fadrozole hydrochloride hemihydrate is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED50 of 0.03 mg/kg when given orally.
Fadrozole hydrochloride hemihydrate prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats.
Administration of Fadrozole hydrochloride hemihydrate in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response.

保存条件：

2-8°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.721 ml	18.605 ml	37.211 ml
5 mM	0.744 ml	3.721 ml	7.442 ml
10 mM	0.372 ml	1.861 ml	3.721 ml
50 mM	0.074 ml	0.372 ml	0.744 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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