| 产品描述： | C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300 |
| 靶点： |
Epigenetic Reader Domain; Wnt/beta-catenin;EpigeneticReaderDomain; Wnt/beta-catenin |
| 体外研究： |
C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs. |
| 体内研究： |
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies shown a very acceptable toxicity profile. |
| 参考文献： |
1. Osawa Y, Oboki K, Imamura J, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015;2(11):1751-1758. Published 2015 Oct 8. doi:10.1016/j.ebiom.2015.10.010 |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.728 ml |
8.64 ml |
17.281 ml |
| 5 mM |
0.346 ml |
1.728 ml |
3.456 ml |
| 10 mM |
0.173 ml |
0.864 ml |
1.728 ml |
| 50 mM |
0.035 ml |
0.173 ml |
0.346 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
