| 产品描述： | LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models |
| 靶点： |
NOP Receptor/ORL1;OpioidReceptor |
| 体内研究： |
LY2940094 (3、10 或 30 mg/kg；2-3 mL/kg；每天口服；持续 4 天) 剂量依赖性地减少印第安纳州酒精偏好 (P) 和马尔基吉安撒丁岛酒精偏好 (msP) 大鼠，不影响食物/水的摄入或运动活动。 Animal Model: Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1] Dosage: 3, 10, or 30 mg/kg; 2-3 mL/kg Administration: Administered orally; daily; 4 days Result: Reduced homecage ethanol self-administration. |
| 参考文献： |
1. Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.079 ml |
10.396 ml |
20.792 ml |
| 5 mM |
0.416 ml |
2.079 ml |
4.158 ml |
| 10 mM |
0.208 ml |
1.04 ml |
2.079 ml |
| 50 mM |
0.042 ml |
0.208 ml |
0.416 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京