| 产品描述： | RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound. |
| 靶点： |
IL-1;Interleukin |
| 体内研究： |
RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745 |
| 参考文献： |
1. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26. 2. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.358 ml |
16.788 ml |
33.577 ml |
| 5 mM |
0.672 ml |
3.358 ml |
6.715 ml |
| 10 mM |
0.336 ml |
1.679 ml |
3.358 ml |
| 50 mM |
0.067 ml |
0.336 ml |
0.672 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京