| 产品描述： | S64315 (MIK665)是Mcl的抑制剂，Ki值为1.2 nM。它具有潜在的促凋亡和抗肿瘤活性 |
| 靶点： |
Mcl-1(Cell-free assay):1.2 nM(Ki);BCL |
| 体外研究： |
S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 |
| 体内研究： |
S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 |
| 细胞实验： |
Cell lines: H929 cells Concentrations: 26 pM (Ki) Incubation Time: 6 h Method: H929 cells were treated for 6 h with increasing concentration of S64315. |
| 动物实验： |
Animal Models: Female CB-17 SCID mice Dosages: 12.5 mg/kg Administration: i.v. |
| 参考文献： |
1. Weiguo Xiang, et al. MCL-1 inhibition in cancer treatment. Onco Targets Ther. 2018, 11:7301-7314. 2. Szlavik Z, et al. Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J Med Chem. 2020 Nov 25;63(22):13762-13795. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.142 ml |
5.712 ml |
11.423 ml |
| 5 mM |
0.228 ml |
1.142 ml |
2.285 ml |
| 10 mM |
0.114 ml |
0.571 ml |
1.142 ml |
| 50 mM |
0.023 ml |
0.114 ml |
0.228 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
