| 产品描述： | DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation |
| 靶点： |
p70S6K;Proteasome |
| 体外研究： |
DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells. DD1 induces cell cycle arrest at G2/M phase and apoptosis. DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation. DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates |
| 参考文献： |
1. Marion Piedfer, et al. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta. 2013 Jun;1833(6):1316-28. |
| 溶解性： |
DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.542 ml |
17.712 ml |
35.424 ml |
| 5 mM |
0.708 ml |
3.542 ml |
7.085 ml |
| 10 mM |
0.354 ml |
1.771 ml |
3.542 ml |
| 50 mM |
0.071 ml |
0.354 ml |
0.708 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
