| 产品描述： | BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. |
| 靶点： |
IC50: 8 nM (BMX), 10.4 nM (BTK);BTK |
| 参考文献： |
1. Feiyang Liu , et al. Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem. Biol., DOI: 10.1021/cb4000629 |
| 溶解性： |
Soluble in DMSO、DMF |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.906 ml |
9.531 ml |
19.063 ml |
| 5 mM |
0.381 ml |
1.906 ml |
3.813 ml |
| 10 mM |
0.191 ml |
0.953 ml |
1.906 ml |
| 50 mM |
0.038 ml |
0.191 ml |
0.381 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京