货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V51862-1ml	10mM in DMSO	￥2450.00 V51862-1ml ￥2450.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V51862-1ml

10mM in DMSO

￥2450.00

货期：3-5天

产品描述：

Otamixaban(FXV673) is an effective (Ki = 0.5 nM), selective, rapid-acting, competitive, and reversible fXa inhibitor. It also effectively inhibits both free and prothrombinase-bound fXa.

靶点：

Others

体内研究：

Otamixaban is highly efficacious in rodent, canine and porcine models of thrombosis showed in vivo experiments. Recent clinical findings indicate that Otamixaban is efficacious, safe, and well-tolerated in humans and therefore has considerable potential for the treatment of acute coronary syndrome.

参考文献：

1. Eikelboom JW, Weitz JI.Otamixaban in acute coronary syndromes.Lancet. 2009 Sep 5;374(9692):762-4. Epub 2009 Aug 28. 2. Sabatine MS, Antman EM, et al. Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial.Lancet. 2009 Sep 5;374(9692):787-95. Epub 2009 Aug 28 3. Guertin, Kevin R.; Choi, Yong-Mi.The discovery of the factor Xa inhibitor Otamixaban: from lead identification to clinical development.Current Medicinal Chemistry (2007), 14(23), 2471-2481. 4. Guertin KR, Choi YM.The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development.Curr Med Chem. 2007;14(23):2471-81. 5. Cohen M, Bhatt DL, et al. SEPIA-PCI Trial Investigators.Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention: the SEPIA-PCI trial.Circulation. 2007

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.23 ml	11.148 ml	22.295 ml
5 mM	0.446 ml	2.23 ml	4.459 ml
10 mM	0.223 ml	1.115 ml	2.23 ml
50 mM	0.045 ml	0.223 ml	0.446 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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