| 体内研究: |
UK 356618 (15 mg/kg;静脉注射;24 小时或 7 天;雄性 Wistar 大鼠) 再灌注处理显著降低大脑中的 MMP3 活性。 |
| 参考文献: |
1. Fray MJ, et al. Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg Med Chem Lett. 2001 Feb 26;11(4):571-4. 2. Yan HQ, et al. Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells. Oncotarget. 2016 Sep 20;7(38):62070-62083. 3. Hafez S, et al. Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. Stroke. 2016 Mar;47(3):843-51. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.793 ml |
8.965 ml |
17.93 ml |
| 5 mM |
0.359 ml |
1.793 ml |
3.586 ml |
| 10 mM |
0.179 ml |
0.897 ml |
1.793 ml |
| 50 mM |
0.036 ml |
0.179 ml |
0.359 ml |
|
| 注意: |
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