| 产品描述： | MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM. |
| 靶点： |
IC50: 16 nM (Human Liver FBPase) |
| 体内研究： |
MB06322 (3/6-300 mg/kg (young/aged Zucker diabetic fatty (ZDF) rats); p.o.; once) results in dose-dependent glucose lowering in young ZDF rats with mild diabetes and aged ZDF rats with overt diabetes Animal Model: ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes)) Dosage: 3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats) Administration: Oral administration; once Result: Results in dose-dependent glucose lowering. |
| 参考文献： |
1. Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5. 2. Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology. 2010 Oct;151(10):4688-95. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.308 ml |
16.54 ml |
33.081 ml |
| 5 mM |
0.662 ml |
3.308 ml |
6.616 ml |
| 10 mM |
0.331 ml |
1.654 ml |
3.308 ml |
| 50 mM |
0.066 ml |
0.331 ml |
0.662 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京