| 产品描述： | HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway |
| 靶点： |
Smo;Hedgehog/Smoothened;Smo |
| 体内研究： |
HhAntag (oral administraion; 75 mg/kg or 100 mg/kg; twice daily; 25 days) results in significant growth delay in HT55 and HT-29 colorectal cell line xenografts models, with average tumour growth inhibitions of 29% and 48%, respectively. Whereas HhAntag had no effect on the growth of DLD-1 xenografts Animal Model: Primary human xenografts in female CD1 nu/nu mice of 6–8 weeks (DLD-1, HT55 and HT-29 cells) Dosage: 75 mg/kg or 100 mg/kg Administration: Oral administraion; twice daily; 25 days Result: Resulted in growth delay of HT55 and HT-29 xenografts, but had no effects on DLD-1 xenografts. |
| 参考文献： |
1. Neeraj Mahindroo, et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorg Med Chem. 2010 Jul 1;18(13):4801-11. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.218 ml |
11.088 ml |
22.177 ml |
| 5 mM |
0.444 ml |
2.218 ml |
4.435 ml |
| 10 mM |
0.222 ml |
1.109 ml |
2.218 ml |
| 50 mM |
0.044 ml |
0.222 ml |
0.444 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京