| 产品描述： | GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ∼30 other kinases. |
| 靶点： |
PLK1:2.2 nM (IC50);PLK3:9.1 nM (IC50);PDGFR1β:160 nM (IC50);VEGFR2:360 nM (IC50);Aurora A:4800 nM (IC50);CDK2/cyclin A:7600 nM (IC50);VEGFR;PLK;CDK;PDGFR;AuroraKinase |
| 参考文献： |
1. Lansing TJ, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31. 2. Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia. Eur J Pharmacol. 2008 Sep 4;591(1-3):102-5. 3. Ikezoe T, et al. A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies. Leukemia. 2009 Sep;23(9):1564-76. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.094 ml |
10.472 ml |
20.944 ml |
| 5 mM |
0.419 ml |
2.094 ml |
4.189 ml |
| 10 mM |
0.209 ml |
1.047 ml |
2.094 ml |
| 50 mM |
0.042 ml |
0.209 ml |
0.419 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京