| 产品描述： | D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1] |
| 靶点： |
IC50: 0.53 μM (tubulin polymerization);MicrotubuleAssociated |
| 体内研究： |
D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model. D-64131 has oral bioavailability and is well tolerated at efficacious doses. Animal Model: Outbred nude mice (6-8 weeks), human amelanoic melanoma MEXF 989 tumor xenograft model Dosage: 200 mg/kg, 400 mg/kg Administration: Oral administration, daily, on days 1-5, 8-9, and 15-18 after xenograft Result: Resulted in significant tumor growth inhibition during treatment. |
| 参考文献： |
1. Thomas Beckers, et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119. 2. S Mahboobi, et al. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J Med Chem. 2001 Dec 20;44(26):4535-53. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.98 ml |
19.898 ml |
39.796 ml |
| 5 mM |
0.796 ml |
3.98 ml |
7.959 ml |
| 10 mM |
0.398 ml |
1.99 ml |
3.98 ml |
| 50 mM |
0.08 ml |
0.398 ml |
0.796 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京