| 产品描述： | DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM. |
| 靶点： |
CK2:0.13 μM (IC50, Human CK2);PIM1:0.148 μM (IC50);PIM2:1.6 μM (IC50);PIM3:0.097 μM (IC50);HIPK2:0.37 μM (IC50);HIPK3:0.59 μM (IC50);DYRK1a:0.41 μM (IC50);DYRK2:0.35 μM (IC50);DYRK3:1.7 μM (IC50);PKD1:0.18 μM (IC50);CDK2:0.64 μM (IC50);CaseinKinase |
| 体内研究： |
DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue |
| 参考文献： |
1. Yde CW, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256(2):229-37. 2. Lawnicka H, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340 3. Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65. 4. Sass G, et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.097 ml |
10.487 ml |
20.974 ml |
| 5 mM |
0.419 ml |
2.097 ml |
4.195 ml |
| 10 mM |
0.21 ml |
1.049 ml |
2.097 ml |
| 50 mM |
0.042 ml |
0.21 ml |
0.419 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京