Ethylenethiourea (10-80 mg/kg; p.o.) is teratogenic in rats. Ethylenethiourea (5-500 ppm; in the diet; 12 month) induces thyroid carcinomas in rats.
参考文献:
1. Khera KS. Ethylenethiourea: teratogenicity study in rats and rabbits. Teratology. 1973 Jun;7(3):243-52. 2. Graham SL, et al. Effects of one-year administration of ethylenethiourea upon the thyroid of the rat. J Agric Food Chem. 1973 May-Jun;21(3):324-9.