货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V52541-1ml	10mM in DMSO	￥10000.00 V52541-1ml ￥10000.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V52541-1ml

10mM in DMSO

￥10000.00

货期：3-5天

产品描述：

Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity. IC50 value: Target: in vitro: squalamine can strongly displace membrane-bound cationic proteins such as Rac1, a ρ-GTPase recruited to the inner leaflet of the eukaryotic cytoplasmic membrane for the actin remodeling necessary for endocytosis. At concentrations between 20 and 60 μg/mL, squalamine has been shown to inhibit a broad array of growth factor-induced, actin-dependent responses in endothelial cells, including cell migration, cell division, and vascular tube formation in a 3D matrix. Squalamine effectively inhibited HBV replication in human primary hepatocytes when added either during the initial exposure of virus to the cells or at 24 h after infection. A similar study was performed to evaluate the effect of squalamine on the replication of HDV. Squalamine was introduced at 20 μg/mL during HDV exposure, and the effects were measured at day 7 when total RNA was extracted and assayed for HDV RNA sequences. in vivo: one time daily treatment with squalamine (15 or 30 mg/kg per d s.c.) was started beginning on day 1 or 2 after viral administration and continuing until day 8 or 9, respectively. Survival was monitored, and animals that remained alive by day 21 were considered cured.

靶点：

Bacterial;HBV;Others

体内研究：

Squalamine (2 mg/kg; 腹腔注射; 28 天) 在乳腺癌异种移植小鼠中抑制肿瘤的生长。
Squalamine (20 mg: 单次涂抹; 0-3 天) 在小鼠模型中对皮肤上的 S. aureus 具有去定植作用。
Squalamine (20-120 mg/kg; 灌胃; 5 天) 可恢复 PD 小鼠模型中肠神经系统的功能。

参考文献：

1. Zasloff M, et al. Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15978-83. 2. Hraiech S, et al. Antibacterial efficacy of inhaled squalamine in a rat model of chronic Pseudomonas aeruginosa pneumonia. J Antimicrob Chemother. 2012 Oct;67(10):2452-8. 3. Djouhri-Bouktab L, et al. Squalamine ointment for Staphylococcus aureus skin decolonization in a mouse model. J Antimicrob Chemother. 2011 Jun;66(6):1306-10.

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.592 ml	7.962 ml	15.925 ml
5 mM	0.318 ml	1.592 ml	3.185 ml
10 mM	0.159 ml	0.796 ml	1.592 ml
50 mM	0.032 ml	0.159 ml	0.318 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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