| 产品描述： | Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. |
| 靶点： |
GNRH Receptor;GNRHReceptor |
| 体内研究： |
Cetrorelix inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model |
| 参考文献： |
1. Yano T , Pinski J , Halmos G , et al. Inhibition of growth of OV-1063 human epithelial ovarian cancer xenografts in nude mice by treatment with luteinizing hormone-releasing hormone antagonist SB-75.[J]. Proceedings of the National Academy of Sciences, 1994, 91(15):7090-7094. 2. Gründker, Carsten, Emons, Günter. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer[J]. Reproductive Biology & Endocrinology Rb & E, 2003, 1(1):65-65. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
0.671 ml |
3.353 ml |
6.707 ml |
| 5 mM |
0.134 ml |
0.671 ml |
1.341 ml |
| 10 mM |
0.067 ml |
0.335 ml |
0.671 ml |
| 50 mM |
0.013 ml |
0.067 ml |
0.134 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京