| 产品描述： | HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1 |
| 靶点： |
IC50: 0.67 μM (PCA-1);Others |
| 体外研究： |
HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells |
| 体内研究： |
HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model. HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration. Animal Model: Nude mice Dosage: 32 mg/kg Administration: Subcutaneous injection; daily; 6 days Result: Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration. |
| 参考文献： |
1. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.141 ml |
15.705 ml |
31.41 ml |
| 5 mM |
0.628 ml |
3.141 ml |
6.282 ml |
| 10 mM |
0.314 ml |
1.57 ml |
3.141 ml |
| 50 mM |
0.063 ml |
0.314 ml |
0.628 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
