| 产品描述： | Collagen proline hydroxylase inhibitor is one member of the collagen proline hydroxylase inhibitor family, which are used as antifibroproliferative agents. Proline hydroxylase is a multiple function oxygenase catalyzing specific prolyl residues in the collagen peptide precursor. Proline hydroxylase has been known as one of the critical enzymes in the biosynthesis of collagen and its activity is enhanced in tissues of various pathological fibrosis. Thus, the specific inhibitor of proline hydroxylase could have clinical application in fibrotic diseases treatment. |
| 靶点： |
Others |
| 体外研究： |
One of collagen proline hydroxylase inhibitors, P-1894B, was found to in vitro inhibit proline hydroxylase and had been proposed as a topical treatment for dermal fibrosis. P-1894B was observed to be with similar activities on one fibroblast line from a patient with infection and two fibroblast lines from normal human skin. 72-hour drug exposure on growing cells showed both time- and dose-dependent inhibition of proliferation. A similar result was also observed in the epithelial cell line NCTC 2544 |
| 参考文献： |
1. Priestley GC. Toxicity of the anthraquinone glycoside P-1894B for human skin fibroblasts. Br J Dermatol.1987 Jul;117(1):67-72. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.822 ml |
14.11 ml |
28.22 ml |
| 5 mM |
0.564 ml |
2.822 ml |
5.644 ml |
| 10 mM |
0.282 ml |
1.411 ml |
2.822 ml |
| 50 mM |
0.056 ml |
0.282 ml |
0.564 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京