| 产品描述: | DMA trihydrochloride is a fluorescent compound (λex=340 nm, λem=478 nm). |
| 靶点: |
IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell);Others |
| 体外研究: |
The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC50 is observed at 5.3 μM for DMA. The IC50 determined in the case of HeLa is 3.4 μM for DMA |
| 参考文献: |
1. Singh M, et al. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles. Eur J Med Chem. 2011 Feb;46(2):659-69. |
| 溶解性: |
Soluble in H2O |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.73 ml |
8.652 ml |
17.303 ml |
| 5 mM |
0.346 ml |
1.73 ml |
3.461 ml |
| 10 mM |
0.173 ml |
0.865 ml |
1.73 ml |
| 50 mM |
0.035 ml |
0.173 ml |
0.346 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |