| 体内研究: |
PCI-27483 shows dose-dependent inhibition of thrombus formation, fibrin accumulation and PT. PCI-27483 (4 mg/kg) shows comparable anticoagulation effects as 2 mg/kg enoxaparin. PCI-27483 (0 and 90 mg/kg, s.c.) results in inhibition of tumor growth in CD1 nu/nu mice implanted with BxPC3 cells. |
| 参考文献: |
1. Gómez-Outes A, et al. New parenteral anticoagulants in development. Ther Adv Cardiovasc Dis. 2011 Feb;5(1):33-59. |
| 溶解性: |
DMSO |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.676 ml |
8.381 ml |
16.763 ml |
| 5 mM |
0.335 ml |
1.676 ml |
3.353 ml |
| 10 mM |
0.168 ml |
0.838 ml |
1.676 ml |
| 50 mM |
0.034 ml |
0.168 ml |
0.335 ml |
|
| 注意: |
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