| 产品描述： | HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM. |
| 体外研究： |
HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 is retested in the dose for their ability to rescue TDP-43. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity, in TDP-43-expressing cells. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM. |
| 参考文献： |
1. Tardiff DF, et al. Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J Biol Chem. 2012 Feb 3;287(6):4107-4120. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.407 ml |
12.034 ml |
24.068 ml |
| 5 mM |
0.481 ml |
2.407 ml |
4.814 ml |
| 10 mM |
0.241 ml |
1.203 ml |
2.407 ml |
| 50 mM |
0.048 ml |
0.241 ml |
0.481 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京