| 靶点: |
Microbial Metabolite;Human Endogenous Metabolite |
| 体内研究: |
Ergothioneine (70 mg/kg, 口服, 连续 14 天) 在大鼠中通过调节 Nrf2、p53 和 NF-κB 信号和抑制 γ-谷氨酰转肽酶介导顺铂引起的肾毒性的改善作用。 |
| 参考文献: |
1. Colognato R, et al. Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. Clin Nutr. 2006 Feb;25(1):135-45. 2. Salama SA, et al. Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase. Life Sci. 2021 Aug 1;278:119572. |
| 溶解性: |
Soluble in water (50 mg/ml), acetone, hot ethanol, and methanol. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
4.361 ml |
21.805 ml |
43.611 ml |
| 5 mM |
0.872 ml |
4.361 ml |
8.722 ml |
| 10 mM |
0.436 ml |
2.181 ml |
4.361 ml |
| 50 mM |
0.087 ml |
0.436 ml |
0.872 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |