| 体内研究: |
Hydronidone (50-100 mg/kg;口服) 可改善 CCl4 和 DDC 诱导的小鼠肝纤维化和肝损伤。 Hydronidone 在 CCl4 和 DDC 诱导的小鼠肝纤维化模型中显著促进活化肝星状细胞 (aHSC) 的凋亡。 |
| 参考文献: |
1. Xu X, et al. Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFβRI. Liver Int. 2023 Nov;43(11):2523-2537. 2. Sun Z, et al. Hydronidone induces apoptosis in activated hepatic stellate cells through endoplasmic reticulum stress-associated mitochondrial apoptotic pathway. J Gastroenterol Hepatol. 2024 Aug;39(8):1695-1703. 3. Juillerat-Jeanneret L, et al. Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. J Med Chem. 2018 Nov 21;61(22):9811-9840. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
4.97 ml |
24.848 ml |
49.697 ml |
| 5 mM |
0.994 ml |
4.97 ml |
9.939 ml |
| 10 mM |
0.497 ml |
2.485 ml |
4.97 ml |
| 50 mM |
0.099 ml |
0.497 ml |
0.994 ml |
|
| 注意: |
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