| 产品描述： | (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor. |
| 靶点： |
D3 Receptor：0.71 nM (Ki)；D2 Receptor：13.5 nM (Ki)；D4 Receptor：3.9-15 nM (Ki)；D5 Receptor：5.4 nM (Ki)；D1 Receptor：83 nM (Ki)；5-HT1A Receptor：30 nM (Ki)；5-HT2B Receptor：27 nM (Ki);DopamineReceptor |
| 参考文献： |
1. Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. 2. Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. 3. Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91. 4. Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.841 ml |
14.207 ml |
28.415 ml |
| 5 mM |
0.568 ml |
2.841 ml |
5.683 ml |
| 10 mM |
0.284 ml |
1.421 ml |
2.841 ml |
| 50 mM |
0.057 ml |
0.284 ml |
0.568 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京