| 体内研究: |
Salvinorin A (intraperitoneal injection; 0.5-2 mg/kg; pre-treatment 30 minutes) at the 0.5 mg/kg dose is the most effective one, at the dose of 0.5 mg/kg, significantly inhibits oedema during the first 6 h; at the dose of 1 mg/kg, salvinorin A significantly reduces the oedema only 4 h after carrageenan injection; at the highest doses tested (2 mg/kg), salvinorin A fails to evoke significant changes on the carrageenan-induced paw oedema. |