| 产品描述： | Ursocholic acid, a bile acid found predominantly in bile of mammals, is transformed into deoxycholic acid by the intestinal microflora in mice. Ursodeoxycholic acid is an inhibitor of 7α-hydroxysteroid dehydrogenase and hepatocyte nuclear factor 1α |
| 靶点： |
Human Endogenous Metabolite;EndogenousMetabolite |
| 体内研究： |
Ursocholic acid (10, 100 和 500 mg/kg, i.g.; 每天 1 次持续 6 天) 显著降低 Sprague -Dawley 大鼠体内炎症细胞因子水平并减少了肠绒毛损伤。 |
| 参考文献： |
1. MacDonald IA, et al. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ 2. Lee HI, et al. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1α, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Nov;52(11):981-5. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.448 ml |
12.238 ml |
24.476 ml |
| 5 mM |
0.49 ml |
2.448 ml |
4.895 ml |
| 10 mM |
0.245 ml |
1.224 ml |
2.448 ml |
| 50 mM |
0.049 ml |
0.245 ml |
0.49 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京